Silverstein Faye S, Jensen Frances E
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-0646, USA.
Ann Neurol. 2007 Aug;62(2):112-20. doi: 10.1002/ana.21167.
In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies have limited efficacy. Although the treatment of neonatal seizures has not significantly changed in the past several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This review includes an overview of current approaches to the diagnosis and treatment of neonatal seizures, identifies some of the critical factors that have limited progress, and highlights recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment.
在儿童期，癫痫发作风险在新生儿期最高。目前使用的疗法疗效有限。尽管在过去几十年里，新生儿癫痫的治疗方法没有显著变化，但在理解影响癫痫发作产生和对抗惊厥药反应性的发育机制方面已经取得了重大进展。本综述包括对新生儿癫痫诊断和治疗的当前方法的概述，确定了一些限制进展的关键因素，并强调了关于新生儿癫痫病理生理学的最新见解，这些见解可能为更好的治疗提供基础。
