新生儿惊厥：发病机制与治疗进展
Neonatal seizures: an update on mechanisms and management.
机构信息
Children's Hospital Boston, CLS 14073, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Clin Perinatol. 2009 Dec;36(4):881-900, vii. doi: 10.1016/j.clp.2009.08.001.
Abstract
The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.
摘要
癫痫发作的寿命风险在新生儿期最高。目前的治疗方法疗效有限。尽管过去几十年中新生儿癫痫的治疗没有显著变化，但在理解影响癫痫发作和对抗癫痫药反应的发育机制方面已经取得了实质性进展。本文概述了目前新生儿癫痫的诊断和治疗方法，并确定了一些关于新生儿癫痫病理生理学的最新见解，这些见解可能为更好的治疗提供基础。
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Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury.临床新生儿惊厥与缺氧缺血性脑损伤风险婴儿的预后独立相关。
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Delayed neural network degeneration after neonatal hypoxia-ischemia.新生儿缺氧缺血后延迟性神经网络退化
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