Children's Hospital Boston, CLS 14073, 300 Longwood Avenue, Boston, MA 02115, USA.
Clin Perinatol. 2009 Dec;36(4):881-900, vii. doi: 10.1016/j.clp.2009.08.001.
The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.
癫痫发作的寿命风险在新生儿期最高。目前的治疗方法疗效有限。尽管过去几十年中新生儿癫痫的治疗没有显著变化，但在理解影响癫痫发作和对抗癫痫药反应的发育机制方面已经取得了实质性进展。本文概述了目前新生儿癫痫的诊断和治疗方法，并确定了一些关于新生儿癫痫病理生理学的最新见解，这些见解可能为更好的治疗提供基础。
