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孕妇及新生儿巨细胞病毒抗体:补体结合试验及间接血凝试验(作者译)

[Cytomegalovirus antibodies in the pregnant female and in the newborn infant complement fixation and indirect hemagglutination tests (author's transl)].

作者信息

Seigneurin S, Longere M

出版信息

Rev Epidemiol Med Soc Sante Publique. 1975 Jun-Aug;23(4-5):297-310.

PMID:176842
Abstract

705 paired sera from mother and infant have been studied at the time of the child birth for the presence of cytomegalovirus antibodies by complement-fixation and indirect hemagglutination tests. 51.3% of those sera were found to have CF antibodies, and 72.8% to have HA antibodies. The indirect hemagglutination test is a more sensitive reaction and detects also IgM antibodies. Chosen sera were fractionated and searched for IgM-HA antibodies to detect CMV congenital infections; only one child was found to be positive. The number of mothers having been in contact with cytomegalovirus was 82.7% (having CF or HA antibodies or both). Immigrant were found to be more often positive than native women (94.3% vs 76.1%); this difference was even greater when CF antibodies alone were considered (74.6% vs 37.7%). Depending on age groups of mothers, the increased number of positives found in CF test was not noticed in HA test.

摘要

在分娩时,通过补体结合试验和间接血凝试验对705对母婴血清进行了研究,以检测巨细胞病毒抗体的存在。发现51.3%的血清有补体结合抗体,72.8%有血凝抗体。间接血凝试验是一种更敏感的反应,还能检测IgM抗体。对挑选出的血清进行分级分离,并寻找IgM-血凝抗体以检测巨细胞病毒先天性感染;仅发现一名儿童呈阳性。接触过巨细胞病毒的母亲比例为82.7%(有补体结合抗体或血凝抗体或两者皆有)。发现移民比本地妇女更常呈阳性(94.3%对76.1%);仅考虑补体结合抗体时,这种差异更大(74.6%对37.7%)。根据母亲的年龄组,在血凝试验中未发现补体结合试验中阳性数量的增加。

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