Blitstein-Willinger E
Department of Clinical Research, Immunology, Schering AG Berlin, FRG.
Skin Pharmacol. 1991;4(3):175-82. doi: 10.1159/000210946.
Numerous growth factors are involved in the regulation of tissue repair and remodelling processes. The repair process is initiated by inflammation, a phenomenon that is regulated by components of the immune response such as cytokines, matrix elements and growth factors. These locally released growth factors or cytokines induce the recruitment, activation, mitogenesis and differentiation of various other cell types. It is improbable that all of them play a key role in the tissue repair process. Obviously, each of these factors may also influence normal tissue homeostasis. Therefore, the possible use of these factors for therapeutic intervention has to be considered carefully. Some of the important aspects of growth factors with regard to this topic will be discussed.
许多生长因子参与组织修复和重塑过程的调节。修复过程由炎症引发，炎症是一种由免疫反应成分如细胞因子、基质成分和生长因子调节的现象。这些局部释放的生长因子或细胞因子诱导各种其他细胞类型的募集、激活、有丝分裂和分化。它们不太可能都在组织修复过程中起关键作用。显然，这些因素中的每一个也可能影响正常组织的稳态。因此，必须仔细考虑将这些因素用于治疗干预的可能性。将讨论与该主题相关的生长因子的一些重要方面。
