Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.
PLoS One. 2007 Aug 8;2(8):e696. doi: 10.1371/journal.pone.0000696.
We present a physical analysis of the dynamics and mechanics of contractile actin rings. In particular, we analyze the dynamics of ring contraction during cytokinesis in the Caenorhabditis elegans embryo. We present a general analysis of force balances and material exchange and estimate the relevant parameter values. We show that on a microscopic level contractile stresses can result from both the action of motor proteins, which cross-link filaments, and from the polymerization and depolymerization of filaments in the presence of end-tracking cross-linkers.
我们对收缩环的动力学和力学特性进行了物理分析。特别是，我们分析了秀丽隐杆线虫胚胎细胞有丝分裂过程中收缩环的收缩动力学。我们对力的平衡和物质交换进行了一般性分析，并估计了相关参数值。结果表明，在微观水平上，收缩应力既可以来自于交联丝的马达蛋白的作用，也可以来自于末端追踪交联剂存在时丝的聚合和解聚。
