年龄对人肝脏组分中对乙酰氨基酚葡萄糖醛酸化和硫酸化的影响。
The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions.
作者信息
Herd B, Wynne H, Wright P, James O, Woodhouse K
机构信息
Department of Medicine (Geriatrics), The University, Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1991 Dec;32(6):768-70.
Abstract
Glucuronidation and sulphation were studied in vitro in human liver samples from 22 subjects aged 40-89 years using paracetamol as substrate. There was no significant correlation with age for the activity of either enzyme pathway. These results provide further evidence that age per se does not have a major effect on the activities of hepatic metabolising enzymes.
摘要
以对乙酰氨基酚为底物，在体外对22名年龄在40至89岁之间的受试者的肝脏样本进行了葡萄糖醛酸化和硫酸化研究。两种酶途径的活性与年龄均无显著相关性。这些结果进一步证明，年龄本身对肝脏代谢酶的活性没有重大影响。
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