Matsuda Tomomichi, Okada Yuji, Inagi Eiji, Tanabe Yasushi, Shimizu Yozo, Nagashima Kazuo, Sakurai Jun, Nagahama Masahiro, Tanaka Shinya
Department of Gastroenterology, Sapporo Higashi-Tokushukai Hospital, Sapporo, Japan.
Pathol Int. 2007 Sep;57(9):622-6. doi: 10.1111/j.1440-1827.2007.02149.x.
Enteritis necroticans 'pigbel' is caused by Clostridium perfringens type C but has rarely been reported in developed countries. A 50-year-old Japanese man with untreated diabetes mellitus (DM) presented with diarrhea and abdominal pain. Intraoperative endoscopic and macroscopic examination disclosed segmental annular mucosal lesions characteristic of clostridial enteritis. Clostridial infection type C was verified on pathological, and immunohistochemical analysis. Although rare, the disease is likely to be underdiagnosed. Hence, the pathology and immunohistochemistry of segmental enteritis with annular mucosal lesions should be examined to establish a diagnosis of enteritis necroticans even in mildly affected patients, and especially those with DM.
坏死性肠炎“猪霍乱”由C型产气荚膜梭菌引起,但在发达国家鲜有报道。一名50岁未治疗的糖尿病日本男性出现腹泻和腹痛。术中内镜及宏观检查发现梭菌性肠炎特征性的节段性环形黏膜病变。病理及免疫组化分析证实为C型梭菌感染。尽管该病罕见,但可能存在诊断不足的情况。因此,即使是轻度受累患者,尤其是糖尿病患者,也应检查节段性肠炎伴环形黏膜病变的病理及免疫组化,以确诊坏死性肠炎。