Staff Anne Cathrine, Braekke Kristin, Johnsen Guro M, Karumanchi S Ananth, Harsem Nina Kittelsen
Department of Obstetrics and Gynecology, Ullevaal University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway.
Am J Obstet Gynecol. 2007 Aug;197(2):176.e1-6. doi: 10.1016/j.ajog.2007.03.036.
We explored whether concentrations of soluble endoglin in fetal serum and amniotic fluid and in maternal serum were elevated in preeclampsia.
Umbilical vein serum, amniotic fluid, and maternal serum from 42 preeclamptic and 43 uncomplicated pregnancies that were delivered by cesarean section were analyzed by enzyme-linked immunosorbent assay for soluble endoglin.
Median maternal serum and amniotic fluid soluble endoglin concentrations were elevated in preeclampsia, compared with control pregnancies (66.9 ng/mL vs 15.1 ng/mL; P < .001, and 1.9 ng/mL vs 0.6 ng/mL; P < .001). Low concentrations of soluble endoglin were found in fetal circulation, which did not differ between preeclampsia and control pregnancies (5.0 ng/mL vs 4.7 ng/mL; P = .2). Maternal serum soluble endoglin levels correlated with circulating soluble fms-like tyrosine kinase 1 concentrations.
We confirmed elevated soluble endoglin in maternal circulation in preeclampsia, which correlated with soluble fms-like tyrosine kinase 1 concentrations and soluble fms-like tyrosine kinase 1/placental growth factor ratio. The fetus appears not to contribute to elevated circulating maternal soluble endoglin concentrations in preeclampsia.
我们探讨了子痫前期患者胎儿血清、羊水及母体血清中可溶性内皮糖蛋白的浓度是否升高。
采用酶联免疫吸附测定法，对42例子痫前期患者及43例剖宫产分娩的无并发症妊娠患者的脐静脉血清、羊水和母体血清中的可溶性内皮糖蛋白进行分析。
与对照妊娠相比，子痫前期患者母体血清和羊水可溶性内皮糖蛋白浓度中位数升高（66.9 ng/mL对15.1 ng/mL；P <.001，以及1.9 ng/mL对0.6 ng/mL；P <.001）。在胎儿循环中发现可溶性内皮糖蛋白浓度较低，子痫前期患者与对照妊娠患者之间无差异（5.0 ng/mL对4.7 ng/mL；P =.2）。母体血清可溶性内皮糖蛋白水平与循环中可溶性fms样酪氨酸激酶1浓度相关。
我们证实子痫前期患者母体循环中可溶性内皮糖蛋白升高，这与可溶性fms样酪氨酸激酶1浓度及可溶性fms样酪氨酸激酶1/胎盘生长因子比值相关。子痫前期患者母体循环中可溶性内皮糖蛋白浓度升高似乎并非胎儿所致。
