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极端长寿人群中的糖尿病

Diabetes mellitus in the extreme longevity.

作者信息

Motta M, Bennati E, Capri M, Ferlito L, Malaguarnera M

机构信息

Department of Senescence Sciences, University of Catania, Cannizzaro Hospital, Via Messina, 829, I-95126 Catania, Italy.

出版信息

Exp Gerontol. 2008 Feb;43(2):102-5. doi: 10.1016/j.exger.2007.06.012. Epub 2007 Jul 4.

DOI:10.1016/j.exger.2007.06.012
PMID:17689906
Abstract

Epidemiological studies have revealed a progressive increase in the prevalence of diabetes mellitus in the elderly. Numerous factors are responsible for this trend, among them there are (a) the long-lasting disease due the improved therapeutic remedial (pharmacological, dietary treatments and physical activity), (b) the increased life span expectancy. The prevalence of diabetes mellitus in long living subjects is lower than in elderly people (subjects aged from 65 to 84). Senile diabetes is prevalent in long living people, and usually begins after 90 years. The incidence of neodiagnosed diabetes is higher in the oldest old than in the elderly people. Based on the results, diabetes mellitus is a negative factor for survival, and does not usually allow to achieve very old age, i.e. centenarian.

摘要

流行病学研究表明,老年人中糖尿病的患病率呈逐渐上升趋势。造成这一趋势的因素众多,其中包括:(a)由于治疗手段(药物、饮食治疗和体育活动)的改善,疾病持续时间延长;(b)预期寿命增加。长寿人群中糖尿病的患病率低于老年人(65至84岁的人群)。老年糖尿病在长寿人群中较为普遍,通常在90岁以后发病。新近诊断出糖尿病的发病率在高龄老人中高于老年人。基于这些结果,糖尿病是影响生存的负面因素,通常使人难以达到非常高的年龄,即百岁高龄。

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