前列腺素E1和E2对豚鼠及大鼠肠道蠕动的影响。
Effect of prostaglandins E1 and E2 on intestinal motility in the guinea-pig and rat.
作者信息
Bennett A, Eley K G, Scholes G B
出版信息
Br J Pharmacol. 1968 Nov;34(3):639-47. doi: 10.1111/j.1476-5381.1968.tb08493.x.
Abstract
- Prostaglandins E(1) and E(2) affected intestinal activity both in vitro and in vivo.2. Serosal application of prostaglandin to guinea-pig isolated ileum stimulated the longitudinal muscle but reduced peristaltic contractions of the circular muscle and the propulsion of fluid through the gut. Intraluminal application had little effect.3. Injection of prostaglandin into the bloodstream of anaesthetized rats stimulated the longitudinal muscle of the ileum and increased the intraluminal pressure. A similar response sometimes occurred in the guinea-pig, but in general the effect was variable.4. Release of prostaglandin in the gut wall, but probably not into the blood or into the lumen of the gut, may play a part in controlling intestinal motility.
摘要
前列腺素E(1)和E(2)在体外和体内均会影响肠道活动。
将前列腺素应用于豚鼠离体回肠的浆膜面，可刺激纵行肌，但会减少环行肌的蠕动收缩以及肠内液体的推进。腔内应用则几乎没有影响。
向麻醉大鼠的血流中注射前列腺素会刺激回肠的纵行肌并增加腔内压力。豚鼠有时会出现类似反应，但总体效果并不稳定。
前列腺素在肠壁内释放，但可能并非进入血液或肠腔，这可能在控制肠道运动中发挥作用。
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