Lerman Caryn, LeSage Mark G, Perkins Kenneth A, O'Malley Stephanie S, Siegel Steven J, Benowitz Neal L, Corrigall William A
Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA.
Nat Rev Drug Discov. 2007 Sep;6(9):746-62. doi: 10.1038/nrd2361.
A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the development of new medications.
尼古丁依赖药物研发的一个主要障碍是缺乏具有足够预测临床有效性的动物和人体实验室模型，以支持从实验室研究到临床研究的知识转化。本综述描述了常用于研究尼古丁依赖病理生理学的动物和人体实验室范式，并提出了如何确定和提高其预测有效性，从而促进新药的研发。
