Bláhová K, Feber J
I. dĕtská klinika 2. lékarské fakulty Univerzity Karlovy, Praha.
Cesk Pediatr. 1991 Feb;46(2):98-100.
The child ingested 7 tabl. of VICEDRIN (a combination of phenacetin, ephedrin, chinin, acid. ascorbicum), the total dose of phenacetin was 140 mg/kg of b.w. Lethal doses of phenacetin vary between 100-200 mg/kg, the sensitivity to phenacetin being increased in infants. Toxicological examination in this case revealed a high concentration of phenacetin in urine. The clinical signs of intoxication were vomiting (hematemesis), methemoglobinemia and somnolence. 2 hemoperfusions were performed lasting 6 hrs and 5 hrs resp. (HEMASORB 400 A 4), the second one were combined with hemodialysis because after the first perfusion a high concentration of metabolic products of phenacetin was detected in urine. After the second perfusion the status of the child rapidly improved and we could discharge the patient of the 10th day after admission. Hemoperfusion is recommended in severe intoxication with phenacetin, the combination with, hemodialysis is possible to remove its metabolic product.
该儿童摄入了7片维西得林（一种由非那西丁、麻黄碱、奎宁、抗坏血酸组成的混合物），非那西丁的总剂量为140毫克/千克体重。非那西丁的致死剂量在100 - 200毫克/千克之间，婴儿对非那西丁的敏感性会增加。该病例的毒理学检查显示尿液中非那西丁浓度很高。中毒的临床症状为呕吐（呕血）、高铁血红蛋白血症和嗜睡。分别进行了持续6小时和5小时的两次血液灌流（HEMASORB 400 A 4），第二次血液灌流与血液透析相结合，因为在第一次灌流后在尿液中检测到高浓度的非那西丁代谢产物。第二次灌流后患儿状况迅速改善，入院第10天我们就让患者出院了。对于非那西丁严重中毒，建议进行血液灌流，结合血液透析有可能清除其代谢产物。
