Rieger C, Geiger S, Herold T, Nickenig C, Ostermann H
Department of Hematology/Oncology, University Hospital Grosshadern, Ludwig Maximilian University, Marchioninistrasse 15, 81377, Munich, Germany.
Eur J Clin Microbiol Infect Dis. 2007 Nov;26(11):843-5. doi: 10.1007/s10096-007-0366-5.
A neutropenic patient with acute myeloid leukaemia experienced a breakthrough infection of Trichosporon asahii during posaconazole treatment. After treatment was changed to a combination therapy with voriconazole and liposomal amphotericin B, the infection resolved. Posaconazole works effectively as an antifungal prophylaxis and salvage therapy in rare invasive fungal infections. This case however illustrates that breakthrough infections with T. asahii may occur during posaconazole treatment.
一名急性髓系白血病的中性粒细胞减少患者在接受泊沙康唑治疗期间发生了阿萨希毛孢子菌突破性感染。治疗改为伏立康唑和脂质体两性霉素B联合治疗后，感染得到缓解。泊沙康唑在罕见的侵袭性真菌感染中作为抗真菌预防和挽救治疗有效。然而，该病例表明在泊沙康唑治疗期间可能发生阿萨希毛孢子菌突破性感染。
