Agnelli Giancarlo, Verso Melina, Ageno Walter, Imberti Davide, Moia Marco, Palareti Gualtiero, Rossi Romina, Pistelli Riccardo
Division of Internal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Via Gerardo Dottori, 06100, Perugia, Italy.
Thromb Res. 2008;121(5):605-10. doi: 10.1016/j.thromres.2007.06.009. Epub 2007 Aug 10.
Information on the epidemiology and long-term clinical outcome of venous thromboembolism (VTE) is mainly based on data from clinical trials and thus may be not representative of the full spectrum of VTE patients. The aim of this multicenter registry (MASTER) was to prospectively collect data on the epidemiology and long-term clinical outcome of VTE in an unselected cohort of patients.
In symptomatic patients with objectively confirmed acute VTE, information about clinical presentation, diagnostic methods, temporary and permanent risk factors, pre-event prophylaxis and treatment were captured by an electronic data network at the time of the index event. A 24-month follow-up is currently ongoing.
From January 2002 to October 2004, 2119 patients were included in the MASTER registry in 25 Italian centers. At entry, the mean patient age was 59.3+/-18.1 years (range 18-99 years). 1541 patients (72.7%) were affected by deep vein thrombosis, 206 patients (9.7%) by pulmonary embolism and 372 patients (17.5%) by both deep vein thrombosis and pulmonary embolism. 676 patients (31.9%) received home-treatment. 899 patients (42.4%) had one or more temporary risk factors. 381 patients (18.0%) had a known cancer at the time of the index event and in 50 patients (2.4%) a new cancer was discovered at the time of the index event. 311 patients (14.7%) had a previous VTE.
Following a real world approach, our registry describes the clinical presentation, risk factors, diagnosis and treatment procedures in a large cohort of unselected patients with VTE.
静脉血栓栓塞症（VTE）的流行病学和长期临床结局信息主要基于临床试验数据，因此可能无法代表所有VTE患者的全貌。本多中心注册研究（MASTER）的目的是前瞻性收集未选择患者队列中VTE的流行病学和长期临床结局数据。
在症状性急性VTE客观确诊患者中，在索引事件发生时通过电子数据网络获取有关临床表现、诊断方法、临时和永久危险因素、事件前预防和治疗的信息。目前正在进行为期24个月的随访。
2002年1月至2004年10月，意大利25个中心的2119例患者纳入MASTER注册研究。入组时，患者平均年龄为59.3±18.1岁（范围18 - 99岁）。1541例患者（72.7%）患有深静脉血栓形成，206例患者（9.7%）患有肺栓塞，372例患者（17.5%）同时患有深静脉血栓形成和肺栓塞。676例患者（31.9%）接受家庭治疗。899例患者（42.4%）有一个或多个临时危险因素。381例患者（18.0%）在索引事件发生时已知患有癌症，50例患者（2.4%）在索引事件发生时发现患有新癌症。311例患者（14.7%）既往有VTE病史。
采用真实世界的方法，我们的注册研究描述了一大群未选择的VTE患者的临床表现、危险因素、诊断和治疗程序。
