Cordero Otto X, Hogeweg P
Department of Theoretical Biology and Bioinformatics, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Trends Genet. 2007 Oct;23(10):488-93. doi: 10.1016/j.tig.2007.07.006. Epub 2007 Aug 10.
Using a large-scale reconstruction of ancestral gene content, we show that radical changes in regulome size occur at the origins of major prokaryotic lineages. Subsequently, the duplication and deletion of regulators slows down in most lineages, except proteobacteria, significantly reducing the scaling of regulators and keeping their average proportion lineage-specific. Our results also suggest that major transitions in prokaryote evolution are related to changes in regulatory capacity rather than proteome innovations.
通过对祖先基因含量进行大规模重建，我们发现原核生物主要谱系起源时调控组大小发生了剧烈变化。随后，除了变形菌门之外，大多数谱系中调控因子的复制和缺失速度减缓，这显著降低了调控因子的增长规模，并使它们的平均比例保持谱系特异性。我们的研究结果还表明，原核生物进化中的主要转变与调控能力的变化有关，而非蛋白质组创新。
