Willitzer H, Tonew M, Lippmann E
Antimicrob Agents Chemother. 1976 Mar;9(3):367-70. doi: 10.1128/AAC.9.3.367.
In a screening program using the agar diffusion-plaque inhibition test, 22 out of 27 substituted aminopyrazoles tested showed marked antiviral activity against mengovirus in FL cell cultures. The efficacy of the different derivatives was compared by determining their effect on the yield of infectious virus after a one-step growth cycle. The antiviral activity against mengovirus correlated with the chain length of the substituents and increased or decreased according to the position of the side chain.
在一项使用琼脂扩散-噬斑抑制试验的筛选计划中，所测试的27种取代氨基吡唑中有22种在FL细胞培养物中对脑心肌炎病毒表现出显著的抗病毒活性。通过测定不同衍生物在一步生长周期后对感染性病毒产量的影响来比较它们的功效。对脑心肌炎病毒的抗病毒活性与取代基的链长相关，并根据侧链的位置而增加或减少。
