关于取代5-氨基-4-氰基吡唑与 Mengovirus 的构效关系的思考。
Considerations on structure-activity relationships with mengovirus of substituted 5-amino-4-cyanopyrazoles.
作者信息
Willitzer H, Tonew M, Lippmann E
出版信息
Antimicrob Agents Chemother. 1976 Mar;9(3):367-70. doi: 10.1128/AAC.9.3.367.
Abstract
In a screening program using the agar diffusion-plaque inhibition test, 22 out of 27 substituted aminopyrazoles tested showed marked antiviral activity against mengovirus in FL cell cultures. The efficacy of the different derivatives was compared by determining their effect on the yield of infectious virus after a one-step growth cycle. The antiviral activity against mengovirus correlated with the chain length of the substituents and increased or decreased according to the position of the side chain.
摘要
在一项使用琼脂扩散-噬斑抑制试验的筛选计划中，所测试的27种取代氨基吡唑中有22种在FL细胞培养物中对脑心肌炎病毒表现出显著的抗病毒活性。通过测定不同衍生物在一步生长周期后对感染性病毒产量的影响来比较它们的功效。对脑心肌炎病毒的抗病毒活性与取代基的链长相关，并根据侧链的位置而增加或减少。
相似文献
1
Considerations on structure-activity relationships with mengovirus of substituted 5-amino-4-cyanopyrazoles.关于取代5-氨基-4-氰基吡唑与 Mengovirus 的构效关系的思考。
Antimicrob Agents Chemother. 1976 Mar;9(3):367-70. doi: 10.1128/AAC.9.3.367.
2
Mode of action in vitro against mengovirus of substituted 5-amino-4-cyanopyrazoles.取代的5-氨基-4-氰基吡唑对脑心肌炎病毒的体外作用模式。
Antimicrob Agents Chemother. 1976 Mar;9(3):371-4. doi: 10.1128/AAC.9.3.371.
3
Antiviral activity of dipyridamole derivatives.双嘧达莫衍生物的抗病毒活性。
Acta Virol. 1978 Jul;22(4):287-95.
4
Dipyridamole, an inhibitor of mengovirus replication in FL and L cells.双嘧达莫，一种在FL和L细胞中抑制脑心肌炎病毒复制的抑制剂。
Chemotherapy. 1977;23(3):149-58. doi: 10.1159/000221983.
5
Effects of pyrimidine derivatives on RNA-dependent RNA polymerase of mengovirus-infected Fogh and Lund (FL) cells.嘧啶衍生物对感染脑心肌炎病毒的福格和伦德（FL）细胞的RNA依赖性RNA聚合酶的影响。
J Gen Virol. 1977 Jan;34(1):37-45. doi: 10.1099/0022-1317-34-1-37.
6
Antiviral 1,3,4-thiadiazoles. I. Action on multiplication of Mengo Virus in FL cells.
Chemotherapy. 1974;20(6):350-60. doi: 10.1159/000221826.
7
Host-dependent restriction of mengovirus replication. IV. Effect of some quaternary ammonium ions on the restricted replication of mengovirus in Madin-Darby bovine kidney cells.宿主依赖性脑心肌炎病毒复制的限制。IV. 某些季铵离子对脑心肌炎病毒在马-达二氏牛肾细胞中受限复制的影响。
J Virol. 1975 Apr;15(4):1033-6. doi: 10.1128/JVI.15.4.1033-1036.1975.
8
Selective irreversible inactivation of replicating mengovirus by nucleoside analogues: a new form of viral interference.核苷类似物对复制中的脑心肌炎病毒的选择性不可逆失活：一种新的病毒干扰形式。
J Virol. 1999 Aug;73(8):6444-52. doi: 10.1128/JVI.73.8.6444-6452.1999.
9
Effect of phleomycin on the replication of mengovirus in novikoff hepatoma cells.博来霉素对诺维科夫肝癌细胞中脑心肌炎病毒复制的影响。
Arch Gesamte Virusforsch. 1973;40(3):265-73. doi: 10.1007/BF01242545.
10
Enhancement of the antiviral activity of pyrimidine derivatives against mengovirus by visible light.可见光增强嘧啶衍生物对脑心肌炎病毒的抗病毒活性。
Zentralbl Bakteriol Orig A. 1979 Sep;244(4):417-26.
引用本文的文献
1
Design, synthesis, and high-throughput anti-cancer evaluation of novel 4-aminopyrazolo[3,4-]pyrimidine derivatives: potential anti-cancer candidates against UO-31 renal cancer cells.新型4-氨基吡唑并[3,4 -]嘧啶衍生物的设计、合成及高通量抗癌评估：针对UO - 31肾癌细胞的潜在抗癌候选物
RSC Adv. 2024 Sep 27;14(42):30938-30953. doi: 10.1039/d4ra05136j. eCollection 2024 Sep 24.
2
Mode of action in vitro against mengovirus of substituted 5-amino-4-cyanopyrazoles.取代的5-氨基-4-氰基吡唑对脑心肌炎病毒的体外作用模式。
Antimicrob Agents Chemother. 1976 Mar;9(3):371-4. doi: 10.1128/AAC.9.3.371.
本文引用的文献
1
[The effect of cycloheximide upon sheep abortion virus, Sindbis virus and other viruses in screening experiments].
Zentralbl Bakteriol Orig. 1969;211(4):437-44.
2
Nucleosides of 2-azapurines and certain ring analogs.2-氮杂嘌呤的核苷及某些环类似物。
J Med Chem. 1972 Feb;15(2):182-7. doi: 10.1021/jm00272a014.
3
Testing of antiviral compounds against Mengo virus infection of mice. I. Screening of compounds and statistical evaluation of their effects.抗 Mengo 病毒感染小鼠的抗病毒化合物测试。I. 化合物筛选及其效果的统计评估。
Chemotherapy. 1974;20(4):235-44. doi: 10.1159/000221813.
4
Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺及相关核苷的设计、合成与广谱抗病毒活性
J Med Chem. 1972 Nov;15(11):1150-4. doi: 10.1021/jm00281a014.
5
[Antiviral activity of imidazole derivatives. I. Inhibition of multiplication of mengovirus in FL cells].[咪唑衍生物的抗病毒活性。I. 对FL细胞中门戈病毒增殖的抑制作用]
Arch Gesamte Virusforsch. 1971;33(3):319-29.
6
Inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues.用嘧啶类似物抑制黏液瘤病毒和纤维瘤病毒形成斑块
Proc Soc Exp Biol Med. 1965 Nov;120(2):496-500. doi: 10.3181/00379727-120-30571.
Zotero 插件