Smith Ken, Rennie Michael J
School of Biomedical Sciences, University of Nottingham at Derby Graduate Entry Medical School, Derby, UK.
Curr Opin Clin Nutr Metab Care. 2007 Sep;10(5):582-90. doi: 10.1097/MCO.0b013e328285d858.
Knowledge of the physiological regulation of human-tissue collagen metabolism in vivo is poor, due to the lack of appropriately robust methods. Recent application of stable isotope tracer techniques to measure human collagen synthesis has provided some insights into the role of nutrition and exercise on collagen turnover in the extracellular matrix of the musculoskeletal system.
Collagen turnover in the musculoskeletal system is faster than previously thought. Bone collagen synthesis is increased by feeding, whereas both muscle collagen and tendon are unresponsive. Exercise stimulates collagen synthesis in both muscle and tendon in an apparently coordinated manner. There are also sex differences and normal aging is associated with increased muscle collagen synthesis and reductions in bone collagen synthesis, particularly in mature bone collagen.
Collagen turnover appears to be faster than previously thought and is regulated by feeding and exercise, in a tissue-specific manner. Further application of these approaches, coupled with measures of gene and protein expression, to measure the acute regulation of collagen, will lead to a better understanding of the physiology and pathophysiology of human collagen turnover. This is particularly important for developing new therapies to improve bone health and minimize tissue fibrosis.
由于缺乏适当有力的方法，目前对于人体组织胶原蛋白代谢的体内生理调节了解不足。稳定同位素示踪技术最近被应用于测量人体胶原蛋白合成，这为营养和运动对肌肉骨骼系统细胞外基质中胶原蛋白周转的作用提供了一些见解。
肌肉骨骼系统中胶原蛋白的周转比之前认为的要快。进食可增加骨胶原蛋白的合成，而肌肉胶原蛋白和肌腱对此无反应。运动以一种明显协调的方式刺激肌肉和肌腱中的胶原蛋白合成。此外还存在性别差异，正常衰老与肌肉胶原蛋白合成增加以及骨胶原蛋白合成减少有关，尤其是成熟骨胶原蛋白。
胶原蛋白周转似乎比之前认为的要快，并且以组织特异性的方式受到进食和运动的调节。进一步应用这些方法，结合基因和蛋白质表达测量，来测定胶原蛋白的急性调节，将有助于更好地理解人体胶原蛋白周转的生理学和病理生理学。这对于开发改善骨骼健康和减少组织纤维化的新疗法尤为重要。
