Memantine-associated reversal of clozapine-induced weight gain.
作者信息
Schaefer M, Leopold K, Hinzpeter A, Heinz A, Krebs M
机构信息
Department of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
出版信息
Pharmacopsychiatry. 2007 Jul;40(4):149-51. doi: 10.1055/s-2007-984391.
INTRODUCTION
Weight gain is a frequently observed adverse event in the treatment with atypical antipsychotics that significantly affects the patients' physical health and treatment compliance.
METHODS
We report on a treatment-resistant schizophrenic patient who received an add-on treatment with the low-affinity NMDA antagonist memantine because of cognitive disturbances.
RESULTS
During this treatment we observed a marked decrease of clozapine-induced weight gain. The causal relationship to memantine could be demonstrated using an on-off-on design with a significant increase of weight after discontinuation and again a substantial weight loss after re-exposition with memantine. Beside weight, also negative symptoms improved.
DISCUSSION
Prospective controlled trials evaluating the safety and possible positive effects of memantine on antipsychotic induced weight gain are needed.
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