Yang Jaewon, Lee Moon-Soo, Joe Sook-Haeng, Jung In-Kwa, Kim Seung-Hyun
Department of Psychiatry, Korea University College of Medicine, Korea University Research Institute of Mental Health, Seoul, South Korea.
Clin Neuropharmacol. 2010 Mar-Apr;33(2):104-6. doi: 10.1097/WNF.0b013e3181c848a0.
Weight gain and metabolic disturbances constitute bothersome problems in schizophrenic patients treated with atypical antipsychotics. Several medications, exercise regimens, and lifestyle changes have been used in attempts to ameliorate these problems. We describe 3 patients with schizophrenia who manifested distinct weight loss and reduction in waist circumference during medication with zonisamide. This report suggests that zonisamide might be associated with weight loss in patients with schizophrenia.
体重增加和代谢紊乱是接受非典型抗精神病药物治疗的精神分裂症患者中令人困扰的问题。人们尝试使用多种药物、运动方案和生活方式改变来改善这些问题。我们描述了3例精神分裂症患者,他们在服用唑尼沙胺期间出现了明显的体重减轻和腰围减小。本报告提示,唑尼沙胺可能与精神分裂症患者的体重减轻有关。