Department of Psychological Medicine, Faculty of Medicine, Colombo, Sri Lanka.
J Psychopharmacol. 2010 Jul;24(7):1127-9. doi: 10.1177/0269881109102530. Epub 2009 Mar 5.
Clozapine is associated with weight gain. We report three patients with substantial weight loss following treatment with clozapine. The weight loss observed in the three patients was 33, 18 and 14.4 kg with percentage loss of body weight of 49, 18 and 21 respectively. Two patients had diabetes mellitus. History, physical examination and extensive investigations in the three patients did not reveal any cause that could account for the weight loss.
氯氮平会导致体重增加。我们报告了三例患者在接受氯氮平治疗后出现明显体重减轻。这 3 例患者的体重分别减轻了 33、18 和 14.4 公斤,体重百分比分别下降了 49%、18%和 21%。其中 2 例患者患有糖尿病。对这 3 例患者的病史、体格检查和广泛的检查并未发现任何可导致体重减轻的原因。