Shibata Takeshi, Hamada Nobushiro, Kimoto Katsuhiko, Sawada Tomofumi, Sawada Tomoji, Kumada Hidefumi, Umemoto Toshio, Toyoda Minoru
Division of Prosthetics, Department of Oral and Maxillofacial Rehabilitation, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka-shi, Kanagawa 238-8580, Japan.
Dent Mater J. 2007 May;26(3):437-44. doi: 10.4012/dmj.26.437.
The purpose of this study was to develop an acrylic resin with antifungal properties by leveraging the photocatalytic activity of apatite-coated titanium dioxide (Ap-TiO2). Candida albicans was used for antifungal activity assay of the specimen plates under ultraviolet A (UVA) with a black light source. Statistically significant decreases in cell viability in acrylic resins containing 5 wt% and 10 wt% Ap-TiO2 were observed after irradiation for two, four, and six hours (P<0.01), when compared to the control. As for the flexural strength and modulus values of acrylic resins mixed with Ap-TiO2 and TiO2 particles, they varied before and after irradiation. Among the tested specimens, a 5 wt% content of Ap-TiO2 in acrylic resin exceeded the requirements of ISO 1567. It was thus suggested that acrylic resin containing 5 wt% Ap-TiO2 could exert antifungal effects on C. albicans, while at the same time maintain adequate mechanical properties for clinical use.
本研究的目的是通过利用磷灰石包覆二氧化钛（Ap-TiO₂）的光催化活性来开发一种具有抗真菌特性的丙烯酸树脂。使用白色念珠菌在紫外A（UVA）和黑色光源下对标本平板进行抗真菌活性测定。与对照组相比，在照射两小时、四小时和六小时后，观察到含有5 wt%和10 wt% Ap-TiO₂的丙烯酸树脂的细胞活力有统计学意义的下降（P<0.01）。至于与Ap-TiO₂和TiO₂颗粒混合的丙烯酸树脂的弯曲强度和模量值，它们在照射前后有所不同。在测试的标本中，丙烯酸树脂中5 wt%的Ap-TiO₂含量超过了ISO 1567的要求。因此表明，含有5 wt% Ap-TiO₂的丙烯酸树脂可以对白色念珠菌发挥抗真菌作用，同时保持适用于临床使用的足够机械性能。
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