Goené Ronnie J, Testori Tiziano, Trisi Paolo
Department of Oral and Maxillofacial Surgery/Pathology, Academic Centre for Dentistry Amsterdam, VU Medical Center, Amsterdam, The Netherlands.
Int J Periodontics Restorative Dent. 2007 Jun;27(3):211-9.
In this prospective randomized controlled clinical study, small titanium implants were placed in posterior maxillae for the purpose of assessing the rate and extent of new bone development. Nine pairs of site evaluation implants were placed in posterior areas of maxillae and retrieved with trephine drills after 4 or 8 weeks of unloaded healing. The amount of bone in linear contact (%) with the implant surface was used to determine the osteoconductive potential of the implant surface. Implant surfaces were dual acid etched (n = 9) (controls) or dual acid etched and further conditioned with nanometer-scale crystals of calcium phosphate (n = 9) (test implants), and the surfaces were compared. The implants and surrounding tissues were processed for histologic analysis. The mean bone-to-implant contact value for the test surface was significantly increased over that of the control implants at both time intervals (P <.01). For the implants/patients included in this study, the addition of a nanometer-scale calcium phosphate treatment to a dual acid-etched implant surface appeared to increase the extent of bone development after 4 and 8 weeks of healing.
在这项前瞻性随机对照临床研究中，将小型钛植入物植入上颌骨后部，以评估新骨形成的速率和范围。在上颌骨后部植入9对位点评估植入物，在4周或8周的无负载愈合后，用环钻取出。与植入物表面呈线性接触的骨量（%）用于确定植入物表面的骨传导潜力。植入物表面进行双酸蚀刻（n = 9）（对照组）或双酸蚀刻并进一步用纳米级磷酸钙晶体处理（n = 9）（测试植入物），并对表面进行比较。对植入物和周围组织进行组织学分析。在两个时间间隔内，测试表面的平均骨与植入物接触值均显著高于对照植入物（P <.01）。对于本研究中纳入的植入物/患者，在双酸蚀刻的植入物表面添加纳米级磷酸钙处理似乎在愈合4周和8周后增加了骨发育的程度。
