细胞角蛋白在化脓性汗腺炎（反向性痤疮）所致鳞状细胞癌中的表达

Cytokeratin expression in squamous cell carcinoma arising from hidradenitis suppurativa (acne inversa).

作者信息

Kurokawa Ichiro, Nishimura Keisuke, Yamanaka Kei-ichi, Mizutani Hitoshi, Tsubura Airo, Revuz Jean

机构信息

Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan.

出版信息

J Cutan Pathol. 2007 Sep;34(9):675-8. doi: 10.1111/j.1600-0560.2006.00680.x.

DOI:10.1111/j.1600-0560.2006.00680.x

PMID:17696913

Abstract

We have studied cytokeratin (CK) expression in two cases of well-differentiated and poorly differentiated squamous cell carcinoma (SCC) arising from hidradenitis suppurativa (HS) (acne inversa). In both cases, type A (infundibular-like keratinized) epithelia were observed. In type A epithelia, CK 1 and 10 expressions were decreased, and CK 14 and 17 were detectable in the whole layers. CK 7, 8, 15, 16 and 18 were not detected in type A epithelia. In tumor nests of well-differentiated SCC, CK 1 and 10 expressions were downregulated, and CK 14 expression was upregulated. In tumor nests of poorly differentiated SCC, CK 1 and 10 were not expressed, but simple epithelial keratins (CK 8, 18 and 19) were expressed. These changes of CK expression are related to malignant transformation from the sinus tract (type A epithelium) in HS to SCC.

摘要

我们研究了两例由化脓性汗腺炎（HS，又称反向性痤疮）引起的高分化和低分化鳞状细胞癌（SCC）中的细胞角蛋白（CK）表达情况。在这两例病例中，均观察到了A型（漏斗状角化样）上皮。在A型上皮中，CK 1和10的表达降低，而CK 14和17在全层均可检测到。在A型上皮中未检测到CK 7、8、15、16和18。在高分化SCC的肿瘤巢中，CK 1和10的表达下调，而CK 14的表达上调。在低分化SCC的肿瘤巢中，未表达CK 1和10，但表达了简单上皮角蛋白（CK 8、18和19）。CK表达的这些变化与HS中窦道（A型上皮）向SCC的恶性转化有关。