Agrawal R, Chansouria J P
Centre of Experimental Medicine and Surgery, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1991 Aug;29(8):767-9.
Adult male albino rats were orally administered 0, 25, 50 and 100 ppm of lead nitrate, mercuric chloride and cadmium chloride for 60, 120 and 180 days. The plasma sodium levels were decreased in rats exposed to varying doses of lead and mercury up to 180 days, while animals which consumed cadmium chloride showed an increase in sodium levels. In lead and mercury treated animals, plasma potassium levels were increased up to 180 days. The levels were decreased in cadmium exposed rats. These observations suggest that chronic exposure to these heavy metals considerably influences plasma sodium and potassium levels depending on the dose and duration of exposure.
成年雄性白化病大鼠分别口服0、25、50和100 ppm的硝酸铅、氯化汞和氯化镉，持续60、120和180天。暴露于不同剂量铅和汞长达180天的大鼠血浆钠水平降低，而摄入氯化镉的动物钠水平升高。在接受铅和汞处理的动物中，血浆钾水平在180天内一直升高。镉暴露大鼠的钾水平降低。这些观察结果表明，长期暴露于这些重金属会根据暴露剂量和持续时间对血浆钠和钾水平产生显著影响。
