Gainer J H
Am J Vet Res. 1977 Jun;38(6):863-7.
Near toxic concentrations of cadmium sulfate, mercuric chloride, and nickel sulfate reduced interferon action in tissue cultures, but increased intake by the intact mouse of lead acetate and mercuric chloride did not reduce interferon action. Lead and nickel given orally inhibited the protective activity of Newcastle disease virus against encephalomyocarditis virus-induced mortality, whereas cadmium, mercury, cobalt sulfate, and sodium arsenite given orally and deficiency of zinc did not influence this action. Excess lead and cobalt and deficiency of zinc, but not excess cadmium, mercury, or nickel, inhibited the protective activity of poly I/poly C against encephalomyocarditis virus-induced mortality. These results illustrate the various actions of increased concentrations of certain metals or a deficiency of zinc on interferon action or on actions of interferon inducers.
接近毒性浓度的硫酸镉、氯化汞和硫酸镍会降低组织培养中的干扰素活性，但完整小鼠摄入增加的醋酸铅和氯化汞却不会降低干扰素活性。口服铅和镍会抑制新城疫病毒对脑心肌炎病毒诱导的死亡率的保护活性，而口服镉、汞、硫酸钴和亚砷酸钠以及锌缺乏则不会影响这种作用。过量的铅和钴以及锌缺乏，但不是过量的镉、汞或镍，会抑制聚肌苷酸/聚胞苷酸对脑心肌炎病毒诱导的死亡率的保护活性。这些结果说明了某些金属浓度增加或锌缺乏对干扰素活性或干扰素诱导剂作用的各种影响。
