Yu H, Yang X-Y, Zhang X, Li Q, Zhu T, Wang Y, Liu B
Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
Anaesthesia. 2007 Sep;62(9):919-22. doi: 10.1111/j.1365-2044.2007.05147.x.
This study was designed to evaluate the effect of diluting fentanyl 50 microg x ml(-1) to 25 or 10 microg x ml(-1) with 0.9% saline and prolonged injection time on fentanyl-induced cough. Two hundred patients requiring general anaesthesia were randomly allocated into four groups: 50 microg x ml(-1) (Group I), 25 microg x ml(-1) (Group II), 10 microg x ml(-1) (Group III) or 10 microg x ml(-1) combined with prolonged injection (Group IV). Fentanyl 3 microg x kg(-1) was administered within 5 s in Groups I, II, and III, or over 30 s in Group IV. Occurrence of cough was significantly reduced in Group IV (2% vs 32%, 16% and 12% in Groups I, II and III, respectively, p < 0.05). There were no statistically significant differences in the severity of coughing between the four groups (p > 0.05). We conclude that dilution of fentanyl to 10 microg x ml(-1) with 0.9% saline combined with a prolonged injection time eliminates fentanyl-induced cough.
本研究旨在评估用0.9%生理盐水将50微克/毫升的芬太尼稀释至25或10微克/毫升以及延长注射时间对芬太尼诱发咳嗽的影响。200例需要全身麻醉的患者被随机分为四组：50微克/毫升（I组）、25微克/毫升（II组）、10微克/毫升（III组）或10微克/毫升并延长注射时间（IV组）。I、II和III组在5秒内给予3微克/千克的芬太尼，IV组在30秒以上给予。IV组咳嗽发生率显著降低（分别为2%，而I、II和III组分别为32%、16%和12%，p<0.05）。四组之间咳嗽严重程度无统计学显著差异（p>0.05）。我们得出结论，用0.9%生理盐水将芬太尼稀释至10微克/毫升并延长注射时间可消除芬太尼诱发的咳嗽。
