极端长寿的代谢方面。

Metabolic aspects of the extreme longevity.

作者信息

Barbieri M, Gambardella A, Paolisso G, Varricchio M

机构信息

Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, I-80138 Napoli, Italy.

出版信息

Exp Gerontol. 2008 Feb;43(2):74-8. doi: 10.1016/j.exger.2007.06.003. Epub 2007 Jun 30.

DOI:10.1016/j.exger.2007.06.003

PMID:17697759

Abstract

Starting from young to very old subjects, aging is associated with a progressive remodeling. Such an age-dependent remodeling process mainly affects anthropometrics, endocrine and thus, also metabolic factors. Interestingly, it occurs in some individuals successfully, while in others unsuccessfully. Centenarians in good health conditions are a very selected group of subjects representing an exceptional condition. Why the centenarians reach the extreme human life span is still unknown. Thus, in this article we will review the best known causes of age-related insulin resistance, outline the main metabolic differences between aged subjects and healthy centenarians, underline the clinical relevance of insulin resistance in the elderly and finally, we will try to propose a unifying hypothesis for explaining the development of insulin resistance with aging.

摘要

从年轻人到年长者，衰老都与渐进性重塑相关。这种与年龄相关的重塑过程主要影响人体测量学、内分泌，进而也影响代谢因素。有趣的是，它在一些个体中成功发生，而在另一些个体中则不然。健康状况良好的百岁老人是经过精心挑选的一组代表特殊情况的受试者。百岁老人为何能达到人类寿命的极限仍是未知。因此，在本文中，我们将回顾与年龄相关的胰岛素抵抗最知名的原因，概述老年受试者与健康百岁老人之间的主要代谢差异，强调胰岛素抵抗在老年人中的临床相关性，最后，我们将尝试提出一个统一的假说来解释胰岛素抵抗随衰老的发展。