Department for Comparative Physiology and Ecophysiology, Institute for Physiology and Biochemistry "Ivan Djaja", Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia.
Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia.
Int J Mol Sci. 2022 Jun 11;23(12):6546. doi: 10.3390/ijms23126546.
Striving for longevity is neither a recent human desire nor a novel scientific field. The first article on this topic was published in 1838, when the average human life expectancy was approximately 40 years. Although nowadays people on average live almost as twice as long, we still (and perhaps more than ever) look for new ways to extend our lifespan. During this seemingly endless journey of discovering efficient methods to prolong life, humans were enthusiastic regarding several approaches, one of which is caloric restriction (CR). Where does CR, initially considered universally beneficial for extending both lifespan and health span, stand today? Does a lifelong decrease in food consumption represent one of the secrets of centenarians' long and healthy life? Do we still believe that if we eat less, we will live longer? This review aims to summarize the current literature on CR as a potential life-prolonging intervention in humans and discusses metabolic pathways that underlie this effect.
追求长寿既不是人类最近的愿望，也不是一个新颖的科学领域。第一篇关于这个主题的文章发表于 1838 年，当时人类的平均预期寿命约为 40 岁。尽管如今人们的平均寿命几乎延长了一倍，但我们仍在（也许比以往任何时候都更）寻找延长寿命的新方法。在这个发现有效延长寿命方法的无尽旅程中，人类对几种方法充满热情，其中之一是热量限制（CR）。最初被认为普遍有益于延长寿命和健康寿命的 CR 如今处于什么地位？终生减少食物摄入是否是长寿健康的百岁老人的秘诀之一？我们是否仍然相信少吃就能长寿？本文旨在总结目前关于热量限制作为人类潜在延寿干预措施的文献，并讨论其潜在的代谢途径。
