Zhang Xiu Li, Jiang Bo, Li Zhi Bo, Hao Shuang, An Li Jia
School of Environmental and Biological Science & Technology, Dalian University of Technology, Dalian, 116024, China.
Pharmacol Biochem Behav. 2007 Nov;88(1):64-72. doi: 10.1016/j.pbb.2007.07.004. Epub 2007 Jul 18.
The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh Rehmannia roots, on the senescent mice induced by D-galactose were assessed. The mice subcutaneously injected with catalpol (5 or 10 mg/kg, 2 weeks, from fifth week) showed significantly improved learning and memory ability in Morris water maze test compared with d-galactose treated mice (150 mg/kg, 6 weeks). We further investigated the mechanism involved in the neuroprotective effects of catalpol on the mice brain tissue. The results showed that catalpol increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), decreased the malondialdehyde (MDA) level, elevated the activities of Na+ -K+ ATPase and Ca2+ -Mg2+ ATPase on the cerebral cortex and hippocampus of d-galactose treated mouse. All the data suggested that catalpol had the potential to be a useful cognitive impairment treatment, and its beneficial effects may be partly mediated via enhancing endogenous antioxidant enzymatic activities and inhibiting free radical generation.
梓醇是从新鲜地黄根中分离得到的一种环烯醚萜苷，本研究评估了其对D-半乳糖诱导的衰老小鼠的神经保护作用。与D-半乳糖处理的小鼠（150 mg/kg，6周）相比，皮下注射梓醇（5或10 mg/kg，2周，从第5周开始）的小鼠在莫里斯水迷宫试验中显示出学习和记忆能力显著提高。我们进一步研究了梓醇对小鼠脑组织神经保护作用的机制。结果表明，梓醇提高了D-半乳糖处理小鼠大脑皮质和海马中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，降低了丙二醛（MDA）水平，提高了Na+-K+ATP酶和Ca2+-Mg2+ATP酶的活性。所有数据表明，梓醇有潜力成为一种有用的认知障碍治疗药物，其有益作用可能部分是通过增强内源性抗氧化酶活性和抑制自由基生成来介导的。
