Adams P A, Berman P A, Egan T J, Marsh P J, Silver J
Department of Clinical Pathology, University of Cape Town Medical School, Cape Town, South Africa.
J Inorg Biochem. 1996 Jul;63(1):69-77. doi: 10.1016/0162-0134(95)00212-x.
Mössbauer spectroscopy has been utilized to probe the electronic environment of iron in a number of Ferriprotoporphyrin IX complexes of relevance to malaria. The markedly different iron environments found for the complexes of hemin with quinine, chloroquine, and the Chinese herbal antimalarial artesunate suggest that these compounds act by protecting the heme from polymerization to insoluble hemozoin, and by facilitating the transport of the protected heme to the food vacuole membrane where it is able to exercise its cytotoxic redox catalytic activity. Mössbauer parameters determined here for purified malaria pigment and synthetic beta-hematin confirm the chemical identical-ness of these species. The Mössbauer spectra of the complexes are discussed in light of the proposed structures of the complexes.
穆斯堡尔光谱已被用于探测与疟疾相关的多种铁原卟啉IX配合物中铁的电子环境。发现血红素与奎宁、氯喹和抗疟中草药青蒿琥酯形成的配合物中铁环境明显不同，这表明这些化合物的作用机制是保护血红素不聚合成不溶性疟色素，并促进受保护的血红素转运至食物泡膜，在那里它能够发挥其细胞毒性氧化还原催化活性。此处测定的纯化疟疾色素和合成β-血红素的穆斯堡尔参数证实了这些物质在化学上的同一性。根据配合物的 proposed 结构对配合物的穆斯堡尔光谱进行了讨论。 （注：原文中“proposed”未翻译完整，可能是“推测的”之类意思，需结合更多背景信息准确翻译）
