Gill Jasmeet K, Maskarinec Gertraud, Wilkens Lynne R, Pike Malcolm C, Henderson Brian E, Kolonel Laurence N
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA.
Am J Epidemiol. 2007 Nov 15;166(10):1150-8. doi: 10.1093/aje/kwm195. Epub 2007 Aug 14.
Previous studies on nonsteroidal antiinflammatory drugs (NSAIDs) and breast cancer have produced mixed results. Incident invasive cases of breast cancer from the Multiethnic Cohort (African Americans, Caucasians, Japanese Americans, Latinas, and Native Hawaiians from Hawaii and California) were identified from 1993 to 2002. Data on aspirin, acetaminophen, and other NSAID (ibuprofen, naproxen, indomethacin) use were based on a self-administered questionnaire at baseline (1993-1996). Multivariate Cox proportional hazards models provided estimates of hazard rate ratios and 95% confidence intervals. The authors observed no associations between breast cancer risk and duration of aspirin use for current or past users (hazard rate ratio = 1.05, 95% confidence interval: 0.88, 1.25 and hazard rate ratio = 1.04, 95% confidence interval: 0.84, 1.27 for > or =6 years of use, respectively) compared with nonusers. However, duration of current other NSAID use was protective (hazard rate ratio = 0.70, 95% confidence interval: 0.51, 0.95 for > or =6 years of use; p(trend) = 0.01) against the risk of breast cancer, while past use was not (hazard rate ratio = 0.90, 95% confidence interval: 0.62, 1.30 for > or =6 years of use). Analyses by ethnicity and hormone receptor status showed that the protective effect of current other NSAID use was limited to Caucasians and African Americans and to women with at least one positive hormone receptor. This study found duration of current other NSAID use to be protective against breast cancer risk.
先前关于非甾体抗炎药（NSAIDs）与乳腺癌的研究结果不一。从多民族队列研究（来自夏威夷和加利福尼亚的非裔美国人、白种人、日裔美国人、拉丁裔和夏威夷原住民）中识别出1993年至2002年期间发生的浸润性乳腺癌病例。关于阿司匹林、对乙酰氨基酚和其他非甾体抗炎药（布洛芬、萘普生、吲哚美辛）使用情况的数据基于基线时（1993 - 1996年）的一份自填问卷。多变量Cox比例风险模型提供了风险率比和95%置信区间的估计值。作者观察到，与未使用者相比，当前或过去使用阿司匹林的时间长短与乳腺癌风险之间无关联（使用≥6年的风险率比 = 1.05，95%置信区间：0.88, 1.25；使用≥6年的风险率比 = 1.04，95%置信区间：0.84, 1.27）。然而，当前使用其他非甾体抗炎药的时间具有预防乳腺癌风险的作用（使用≥6年的风险率比 = 0.70，95%置信区间：0.51, 0.95；p趋势 = 0.01），而过去使用则不然（使用≥6年的风险率比 = 0.90，95%置信区间：0.62, 1.30）。按种族和激素受体状态进行的分析表明，当前使用其他非甾体抗炎药的保护作用仅限于白种人和非裔美国人以及至少有一个阳性激素受体的女性。本研究发现，当前使用其他非甾体抗炎药的时间对乳腺癌风险具有预防作用。
