Melville Amanda J, Rodríguez-Lorenzo Luis M, Forsythe John S
Department of Materials Engineering, Division of Biological Engineering, Monash University, Melbourne, Australia.
J Mater Sci Mater Med. 2008 Mar;19(3):1187-95. doi: 10.1007/s10856-007-3185-4. Epub 2007 Aug 15.
The effects of heat treatment time and temperature on the delivery behaviour of Ibuprofen from hydroxyapatite particles were investigated in this study. The drug release was seen to follow Fickian diffusion for the initial period of release for all heat treatment conditions. The gradient of Fickian release increased with (1) increasing crystallite size, attributed to the decreasing amount of boundary area, and (2) with decreasing surface area, due to the reduction in porosity and hence tortuosity within the apatite particles. This study has shown that altering the heat treatment conditions used to calcine hydroxyapatite may alter its drug delivery abilities, whereby calcination temperature was noted to influence the drug release behaviour to a greater extent than calcination time.
本研究考察了热处理时间和温度对布洛芬从羟基磷灰石颗粒中释放行为的影响。在所有热处理条件下，药物释放初期均符合菲克扩散。菲克释放的梯度随着以下因素增加：（1）晶粒尺寸增大，这归因于边界面积的减少；（2）表面积减小，这是由于磷灰石颗粒内孔隙率降低以及曲折度减小所致。本研究表明，改变用于煅烧羟基磷灰石的热处理条件可能会改变其药物递送能力，其中煅烧温度对药物释放行为的影响程度大于煅烧时间。
