Hillig William B, Choi Y, Murthy S, Natravali N, Ajayan P
Department of Material Science and Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.
J Mater Sci Mater Med. 2008 Jan;19(1):11-7. doi: 10.1007/s10856-007-0154-x. Epub 2007 Aug 15.
Gelatin matrix composites reinforced with fine hydroxyapatite (HA) dispersants were investigated in an exploratory study for their suitability as surgical implants. The criteria for the candidate implant material were that it: (1) be benign, (2) have useful mechanical properties under quasi-in vivo environmental conditions, (3) be dimensionally stable, (4) be sterilizable, (5) be completely assimilable, and (6) exhibit contiguous porosity to encourage invasion by the live host tissue. The synthesis of a composite comprised of a HA particulate reinforcement of a cross-linked gelatin matrix was undertaken to provide preliminary data on its swelling behavior and compressive stiffness that is retained after extended immersion in normal saline solution. A new approach leading to a tailorable, open pore microstructure is described. At a sufficiently high ratio of HA to gelatin the attainable compressive stiffness and the resistance to swelling suggests that this composite system offers potential as a versatile surgical implant material. Suggestions for further studies are offered.
在一项探索性研究中，对用细羟基磷灰石（HA）分散剂增强的明胶基复合材料作为外科植入物的适用性进行了研究。候选植入材料的标准是：（1）良性；（2）在准体内环境条件下具有有用的机械性能；（3）尺寸稳定；（4）可消毒；（5）完全可吸收；（6）具有连续孔隙以促进宿主活组织的侵入。合成了一种由交联明胶基质的HA颗粒增强体组成的复合材料，以提供其在生理盐水中长时间浸泡后保留的溶胀行为和压缩刚度的初步数据。描述了一种产生可定制的开孔微观结构的新方法。在HA与明胶的比例足够高时，可达到的压缩刚度和抗溶胀性表明，这种复合体系作为一种通用的外科植入材料具有潜力。还提供了进一步研究的建议。
