Trinh Quang Duy, Pham Ngan Thi Kim, Nguyen Tuan Anh, Phan Tung Gia, Khamrin Pattara, Yan Hainian, Hoang Phuc Le, Maneekarn Niwat, Li Yan, Kozlov Vladimir, Kozlov Alexei, Okitsu Shoko, Ushijima Hiroshi
Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
J Med Virol. 2007 Oct;79(10):1611-6. doi: 10.1002/jmv.20931.
The distribution of rotavirus G-types in the world appears to be changing, especially with the emergence of G3 and G9 in many countries. Sequence analysis of the VP7 gene was performed on the 27 human G3 rotavirus strains isolated in China, Russia, Thailand, and Vietnam during 2001-2004. All the strains studied were clustered into the same branch of the phylogenetic tree. The comparison of the G3 deduced amino acid sequences between the studied Chinese strains and the strains circulating in China during 1986-1992 showed a wide range of amino acid substitutions (up to 13 amino acids in the VP7 antigenic regions). The two considerable changes both from aspartic acid to asparagine were located at positions 96 in antigenic region A and 213 in antigenic region C. Those amino acid substitutions of the Chinese G3 strains might involve in the emergence of G3 rotavirus in China during 2001-2003.
世界范围内轮状病毒G型的分布似乎正在发生变化，尤其是许多国家出现了G3和G9型。对2001年至2004年期间在中国、俄罗斯、泰国和越南分离出的27株人G3轮状病毒毒株进行了VP7基因的序列分析。所有研究的毒株都聚集在系统发育树的同一分支中。将研究的中国毒株与1986年至1992年期间在中国流行的毒株的G3推导氨基酸序列进行比较，发现存在广泛的氨基酸替换（VP7抗原区域中多达13个氨基酸）。两个显著的变化均为天冬氨酸变为天冬酰胺，分别位于抗原区域A的第96位和抗原区域C的第213位。中国G3毒株的这些氨基酸替换可能与2001年至2003年期间中国G3轮状病毒的出现有关。
