Tillmann Thomas, Ernst Heinrich, Ebert Sven, Kuster Niels, Behnke Wolfgang, Rittinghausen Susanne, Dasenbrock Clemens
Fraunhofer-Institute of Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany.
Bioelectromagnetics. 2007 Apr;28(3):173-87. doi: 10.1002/bem.20283.
The purpose of this study using a total of 1170 B6C3F1 mice was to detect and evaluate possible carcinogenic effects in mice exposed to radio-frequency-radiation (RFR) from Global System for Mobile Communication (GSM) and Digital Personal Communications System (DCS) handsets as emitted by handsets operating in the center of the communication band, that is, at 902 MHz (GSM) and 1747 MHz (DCS). Restrained mice were exposed for 2 h per day, 5 days per week over a period of 2 years to three different whole-body averaged specific absorption rate (SAR) levels of 0.4, 1.3, 4.0 mW/g bw (SAR), or were sham exposed. Regarding the organ-related tumor incidence, pairwise Fisher's test did not show any significant increase in the incidence of any particular tumor type in the RF exposed groups as compared to the sham exposed group. Interestingly, while the incidences of hepatocellular carcinomas were similar in EMF and sham exposed groups, in both studies the incidences of liver adenomas in males decreased with increasing dose levels; the incidences in the high dose groups were statistically significantly different from those in the sham exposed groups. Comparison to published tumor rates in untreated mice revealed that the observed tumor rates were within the range of historical control data. In conclusion, the present study produced no evidence that the exposure of male and female B6C3F1 mice to wireless GSM and DCS radio frequency signals at a whole body absorption rate of up to 4.0 W/kg resulted in any adverse health effect or had any cumulative influence on the incidence or severity of neoplastic and non-neoplastic background lesions, and thus the study did not provide any evidence of RF possessing a carcinogenic potential.
本研究共使用了1170只B6C3F1小鼠，目的是检测和评估暴露于全球移动通信系统（GSM）和数字个人通信系统（DCS）手机发出的射频辐射（RFR）下的小鼠可能产生的致癌作用，这些手机在通信频段中心发射，即902兆赫兹（GSM）和1747兆赫兹（DCS）。将受约束的小鼠每天暴露2小时，每周5天，持续2年，暴露于三种不同的全身平均比吸收率（SAR）水平，分别为0.4、1.3、4.0毫瓦/克体重（SAR），或进行假暴露。关于器官相关肿瘤发生率，与假暴露组相比，成对Fisher检验未显示射频暴露组中任何特定肿瘤类型的发生率有任何显著增加。有趣的是，虽然电磁辐射暴露组和假暴露组的肝细胞癌发生率相似，但在两项研究中，雄性小鼠肝腺瘤的发生率均随剂量水平的增加而降低；高剂量组的发生率与假暴露组有统计学显著差异。与未处理小鼠公布的肿瘤发生率进行比较发现，观察到的肿瘤发生率在历史对照数据范围内。总之，本研究没有证据表明，雄性和雌性B6C3F1小鼠以高达4.0瓦/千克的全身吸收率暴露于无线GSM和DCS射频信号下会导致任何不良健康影响，或对肿瘤性和非肿瘤性背景病变的发生率或严重程度有任何累积影响，因此该研究没有提供任何证据表明射频具有致癌潜力。
