Kalmanti Elina, Maris Thomas G
Department of Pathology , University of Crete Medical School, Heraklion, Crete, Greece.
In Vivo. 2007 Jul-Aug;21(4):641-6.
The fractal dimension (FD) of the cerebral cortex was measured in 93 individuals, aged from 3 months to 78 years, with normal brain MRI's in order to compare the convolutions of the cerebral cortex between genders and age groups. Image J, an image processing program, was used to skeletonize cerebral cortex and the box counting method applied. FDs on slices taken from left and right hemispheres were calculated. Our results showed a significant degree of lateralization in the left hemisphere. It appears that basal ganglia development, mainly in the left hemisphere, is heavily dependent upon age until puberty. In addition, both left and right cortex development equally depends on age until puberty, while the corresponding right hemisphere convolutions continue to develop until a later stage. An increased developmental activity appears between the ages of 1 and 15 years, indicating a significant brain remodelling during childhood and adolescence. In infancy, only changes in basal ganglia are observed, while the right hemisphere continues to remodel in adulthood.
为了比较不同性别和年龄组之间大脑皮质的脑回情况，对93名年龄在3个月至78岁之间、脑部MRI正常的个体测量了大脑皮质的分形维数（FD）。使用图像处理程序Image J对大脑皮质进行骨架化处理，并应用盒计数法。计算了从左、右半球获取的切片上的FD。我们的结果显示左半球存在显著的偏侧化现象。似乎基底神经节的发育，主要是左半球的发育，在青春期前严重依赖于年龄。此外，左、右皮质的发育在青春期前同样依赖于年龄，而相应的右半球脑回在更晚的阶段仍继续发育。在1岁至15岁之间出现了增强的发育活动，表明在儿童期和青少年期大脑发生了显著的重塑。在婴儿期，仅观察到基底神经节的变化，而右半球在成年期继续重塑。
