Leygue Etienne
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Nucl Recept Signal. 2007 Aug 3;5:e006. doi: 10.1621/nrs.05006.
The steroid receptor RNA activator (SRA) is a unique modulator of steroid receptor transcriptional activity, as it is able to mediate its coregulatory effects as a RNA molecule. Recent findings, however, have painted a more complex picture of the SRA gene (SRA1) products. Indeed, even though SRA was initially thought to be noncoding, several RNA isoforms have now been found to encode an endogenous protein (SRAP), which is well conserved among Chordata. Although the function of SRAP remains largely unknown, it has been proposed that, much like its corresponding RNA, the protein itself might regulate estrogen and androgen receptor signaling pathways. As such, data suggest that both SRA and SRAP might participate in the mechanisms underlying breast, as well as prostate tumorigenesis. This review summarizes the published literature dealing with these two faces of the SRA gene products and underscores the relevance of this bifaceted system to breast cancer development.
类固醇受体RNA激活剂（SRA）是类固醇受体转录活性的一种独特调节剂，因为它能够作为一种RNA分子介导其共调节作用。然而，最近的研究结果描绘了一幅关于SRA基因（SRA1）产物的更为复杂的图景。事实上，尽管SRA最初被认为是非编码的，但现在已经发现几种RNA异构体能够编码一种内源性蛋白质（SRAP），这种蛋白质在脊索动物中高度保守。尽管SRAP的功能在很大程度上仍然未知，但有人提出，与其相应的RNA非常相似，该蛋白质本身可能调节雌激素和雄激素受体信号通路。因此，数据表明SRA和SRAP可能都参与了乳腺癌以及前列腺癌发生的潜在机制。这篇综述总结了已发表的关于SRA基因产物这两个方面的文献，并强调了这个双面系统与乳腺癌发展的相关性。
