Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
FEBS Lett. 2010 Mar 19;584(6):1174-80. doi: 10.1016/j.febslet.2010.02.024. Epub 2010 Feb 11.
The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA-RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response-element dependent manner. Our data therefore suggest that both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors.
类固醇受体 RNA 激活物基因（SRA1）编码一种功能性 RNA（SRA）和一种蛋白质（SRAP）。虽然有几个研究小组报告了 SRA-RNA 的作用机制，但 SRAP 的确切功能仍有待阐明，主要是因为缺乏独立于其 RNA 对应物研究该蛋白质功能的研究。使用两种独立的模型来研究其特定功能，发现 SRAP 以配体和反应元件依赖的方式增强雌激素受体 alpha 的活性。因此，我们的数据表明，SRA1 基因的转录本和蛋白质产物共同调节类固醇受体的转录活性。
