Guttormsen A B, Johansson S G O, Oman H, Wilhelmsen V, Nopp A
Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.
Allergy. 2007 Nov;62(11):1326-30. doi: 10.1111/j.1398-9995.2007.01498.x. Epub 2007 Aug 20.
The general understanding is that a blood sample for analysis of immunoglobulin (Ig) E antibodies to an allergen suspected to cause an anaphylaxis cannot be drawn until several weeks after the reaction. As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluate the possibility of using samples drawn at the time of the reaction.
Immunoglobulin E antibodies to suxamethonium were quantitated with ImmunoCAP before, during and after an anaphylactic reaction occurring during anaesthesia using neuromuscular blocking agents.
Serum IgE antibody concentrations against suxamethonium in blood samples collected up to 6 h after the reaction were not different from those in samples drawn before or days and weeks after the anaphylaxis.
A serum sample intended to trace the drug involved in an IgE-mediated anaphylactic reaction can be drawn in direct relation to the reaction.
一般的认识是，用于分析针对疑似引起过敏反应的过敏原的免疫球蛋白（Ig）E抗体的血样，要在反应发生数周后才能采集。由于这极不实用，因此研究了过敏反应期间IgE抗体水平的变化，以评估使用反应发生时采集的样本的可能性。
在使用神经肌肉阻滞剂麻醉期间发生过敏反应之前、期间和之后，用免疫捕获法对琥珀酰胆碱的免疫球蛋白E抗体进行定量。
在反应后6小时内采集的血样中，针对琥珀酰胆碱的血清IgE抗体浓度与过敏反应前、以及过敏反应后数天和数周采集的样本中的浓度没有差异。
旨在追踪IgE介导的过敏反应中所涉及药物的血清样本，可以在与反应直接相关的时间采集。
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