Shimizu Takeru, Takahashi Hiroshi, Matsumiya Naoki, Miyabe Masayuki, Tanaka Makoto
Department of Anesthesiology, University of Tsukuba, Tsukuba 305-8575.
Masui. 2007 Aug;56(8):949-52.
A 31-year-old woman with primary pulmonary hypertension presented for an elective cesarean section at the 34-week gestation. After monitoring pulmonary artery, systemic artery blood pressures and an electrocardiogram, continuous lumbar epidural anesthesia was performed. Uneventful delivery was followed by a sudden decrease in systemic pressure and loss of consciousness. Her trachea was intubated and administration of epinephrine was started. Nitroprusside and milrinone were infused to decrease pulmonary artery pressure and to maintain systemic arterial pressure. However, she died after 16 hours due to an impairment of right ventricular function. Although the patient with PPH had been managed successfully using continuous epidural analgesia until delivery, sudden hemodynamic alterations following delivery could not be controlled by pharmacological interventions.
一名31岁的原发性肺动脉高压女性患者,在妊娠34周时行择期剖宫产。监测肺动脉、体动脉血压及心电图后,实施连续腰段硬膜外麻醉。分娩过程顺利,但随后出现体循环压力突然下降及意识丧失。立即行气管插管并开始给予肾上腺素。输注硝普钠和米力农以降低肺动脉压并维持体循环动脉压。然而,患者在16小时后因右心室功能损害死亡。尽管该原发性肺动脉高压患者在分娩前一直通过连续硬膜外镇痛成功管理,但分娩后突发的血流动力学改变无法通过药物干预控制。