来自斐济红藻锯齿卡洛藻的卡洛藻酸和卡洛藻醇。
Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.
作者信息
Lane Amy L, Stout Elizabeth P, Hay Mark E, Prusak Anne C, Hardcastle Kenneth, Fairchild Craig R, Franzblau Scott G, Le Roch Karine, Prudhomme Jacques, Aalbersberg William, Kubanek Julia
机构信息
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
出版信息
J Org Chem. 2007 Sep 14;72(19):7343-51. doi: 10.1021/jo071210y. Epub 2007 Aug 23.
Abstract
Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.
摘要
从斐济红藻锯齿美羽藻（Callophycus serratus）的提取物中分离出了羽藻酸A - H（1 - 8）以及羽藻醇A和B（9和10），并通过核磁共振、X射线和质谱分析对其进行了鉴定。这些天然产物代表了四种新型碳骨架，是大型藻类中二萜 - 苯甲酸和二萜 - 酚的首个实例。化合物1 - 10表现出抗菌、抗疟和抗癌活性，不过它们的生物活性比先前从这种红藻中分离出的二萜 - 苯甲酸大环内酯类化合物要低。
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