School of Biology and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
J Nat Prod. 2010 Feb 26;73(2):275-8. doi: 10.1021/np900686w.
Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.
从斐济红藻 Callophycus serratus 中分离得到四个新的溴藻酚内酯 R-U（1-4），并通过 1D 和 2D NMR 以及质谱分析鉴定。这些化合物扩展了二萜苯甲酸大环内酯的已知结构多样性，并对选定的人类癌细胞系表现出适度的细胞毒性。溴藻酚内酯 S（2）对人类疟原虫 Plasmodium falciparum 也表现出亚微摩尔的活性。
