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卤代二萜类化合物具有体外抗肿瘤活性的红藻。

Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga .

机构信息

Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil.

出版信息

Mar Drugs. 2019 Dec 29;18(1):29. doi: 10.3390/md18010029.

DOI:10.3390/md18010029

PMID:31905719

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7024270/

Abstract

Eight new (-) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds and were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC values 15 and 16 μM, respectively.

摘要

从希腊爱奥尼亚海沿岸采集的红藻有机提取物中分离得到了八种新型（-）结构多样的二萜类化合物，具有五种不同的碳环。基于全面的光谱分析，包括 NMR 和高分辨率质谱 (HRMS) 数据，确定了这些新天然产物的结构，其中七种是卤化的，以及它们的手性中心的相对构型。化合物和被发现具有体外抗肿瘤活性，对一株鼠和五株人癌细胞系的平均 IC 值分别为 15 和 16 μM。