Haga Kristin K, Khor Yuet Peng, Farrall Andrew, Wardlaw Joanna M
Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Neurobiol Aging. 2009 Mar;30(3):353-63. doi: 10.1016/j.neurobiolaging.2007.07.005. Epub 2007 Aug 23.
(1)H MR spectroscopy (MRS) can identify metabolite abnormalities in age-related, neurological diseases. However, there is little information on how metabolites change with healthy aging.
We systematically reviewed the literature on MRS, from 1980 to 2006, for studies where healthy young subjects (<60 years) were compared to healthy older subjects (>60 years). We extracted metabolite data reported as "no change", "increase" or "decrease" for each metabolite by brain region and, where data were available, meta-analysed mean metabolite concentrations (mM) for young versus old subjects.
Eighteen studies met the inclusion criteria (total n=703 subjects, 284 >60 years old). Most data came from the frontal region, and reported "no change" in older subjects; however, a meta-analysis revealed a decrease in frontal NAA (p=0.05) and increases in parietal choline (p=0.003) and creatine (p<0.001).
These data suggest that NAA may decrease and choline and creatine increase with age. Therefore, more data are needed from older subjects to characterise age effects better and ratios in older subjects should be interpreted with caution.
氢质子磁共振波谱（MRS）能够识别与年龄相关的神经疾病中的代谢物异常情况。然而，关于健康衰老过程中代谢物如何变化的信息却很少。
我们系统回顾了1980年至2006年期间有关MRS的文献，查找那些将健康年轻受试者（<60岁）与健康老年受试者（>60岁）进行比较的研究。我们提取了按脑区报告为“无变化”“增加”或“减少”的每种代谢物的数据，并在有数据的情况下，对年轻与老年受试者的平均代谢物浓度（mM）进行荟萃分析。
18项研究符合纳入标准（总样本量n = 703名受试者，其中284名年龄>60岁）。大多数数据来自额叶区域，报告老年受试者“无变化”；然而，荟萃分析显示额叶NAA减少（p = 0.05），顶叶胆碱增加（p = 0.003），肌酸增加（p < 0.001）。
这些数据表明，随着年龄增长，NAA可能减少，胆碱和肌酸可能增加。因此，需要更多来自老年受试者的数据以更好地描述年龄效应，并且在解释老年受试者中的比率时应谨慎。
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