Cortelli P, Pierangeli G, Parchi P, Contin M, Baruzzi A, Lugaresi E
Neurological Institute, University of Bologna Medical School, Italy.
Headache. 1991 Jul;31(7):457-62. doi: 10.1111/j.1526-4610.1991.hed3107457.x.
Autonomic nervous system functions were studied in 13 females with migraine without aura during headache-free intervals, using physiological, pharmacological and biochemical methods. Heart-rate in the resting condition and blood pressure rises in the cold-face and isometric handgrip tests were higher than in controls. Normal cardiovascular responses to the Valsalva manoeuvre and to noradrenaline infusion suggest that the baroreflex arc is intact. Normal heart rate responses to the Valsalva manoeuvre, to the cold-face test and to deep breathing confirmed a normal cardiac parasympathetic function. Clonidine infusion showed a sedative and depressor effect and an inhibition of plasma NA similar to those occurring in controls, suggesting a normal central sympathetic tone. As a whole, the physiological, pharmacological and biochemical tests were consistent with a non-specific sympathetic hyperactivity, but do not confirm any impairment of the autonomic control of the cardiovascular system in migraine patients in headache-free intervals.
在13名无先兆偏头痛女性的头痛缓解期，运用生理学、药理学及生物化学方法对其自主神经系统功能进行了研究。静息状态下的心率以及冷脸试验和等长握力试验中的血压升高幅度均高于对照组。对瓦尔萨尔瓦动作和去甲肾上腺素输注的正常心血管反应表明压力反射弧完整。对瓦尔萨尔瓦动作、冷脸试验和深呼吸的正常心率反应证实心脏副交感神经功能正常。可乐定输注显示出与对照组相似的镇静、降压作用以及对血浆去甲肾上腺素的抑制作用，提示中枢交感神经张力正常。总体而言，生理学、药理学及生物化学测试结果与非特异性交感神经功能亢进相符，但并未证实偏头痛患者在头痛缓解期存在心血管系统自主控制功能的任何损害。
