Heye N, Zimmer C, Terstegge K, Sirtl C, Cervós-Navarro J
Neurological Clinic St. Josefs-Hospital, Universität Bochum, FRG.
Intensive Care Med. 1991;17(7):432-4. doi: 10.1007/BF01720685.
The case of a 55-year-old female with oxalate-induced lethal encephalitis following infusions of sugar surrogates is reported. Renal failure and subsequent central coma developed following the use of xylitol, fructose and sorbitol above the recommended dosages. The patient died due to raised intracranial pressure. Cerebral damage was caused by encephalitis due to calcium oxalate crystals. Oxalosis induced by sugar surrogates may be explained either by dose-dependent toxic effects or genetically fixed intolerance.
报告了一例55岁女性在输注糖替代品后发生草酸盐诱导的致死性脑炎的病例。在使用高于推荐剂量的木糖醇、果糖和山梨醇后，出现了肾衰竭及随后的中枢性昏迷。患者因颅内压升高而死亡。脑损伤是由草酸钙晶体引起的脑炎所致。糖替代品引起的草酸中毒可能是由剂量依赖性毒性作用或遗传固定的不耐受性所解释。
