Galaske R G, Burdelski M, Brodehl J
Dtsch Med Wochenschr. 1986 Jun 20;111(25):978-83. doi: 10.1055/s-2008-1068568.
Four children (aged 2 1/2-14 years) were given infusions of fructose, sorbitol and xylitol after sustaining head trauma (n = 3) or after attempted suicide with carbromal (n = 1). After transitory polyuria renal failure of varying severity set in three to five days after onset of the infusion treatment. Serum osmolality fell to 265-274 mosm/kg, haematocrit to 0.25-0.31, and hyponatraemia developed. Serum creatinine rose to maximally 256-930 mumol/l. Liver damage developed in parallel to the renal failure, two children dying with acute yellow liver atrophy. Two children--given symptomatic treatment with balanced equalization of the hyponatraemia, administration of frusemide and adjusted carbohydrate substitution--were discharged after four to eight weeks with normal renal and hepatic functions. Dialysis was not required. The hepatic and renal abnormalities must have been due to the high amounts of fructose, sorbitol and xylitol, to a total of 7.1-23.0 g/kg on the first day, well above recommended levels.
4名儿童（年龄在2岁半至14岁之间）在遭受头部创伤（3例）或服用水合氯醛自杀未遂（1例）后接受了果糖、山梨醇和木糖醇输注。输注治疗开始后三至五天，出现了不同程度的短暂性多尿性肾衰竭。血清渗透压降至265 - 274 mosm/kg，血细胞比容降至0.25 - 0.31，并出现低钠血症。血清肌酐最高升至256 - 930 μmol/l。肝损伤与肾衰竭同时出现，2名儿童死于急性黄色肝萎缩。2名接受低钠血症平衡对症治疗、给予速尿并调整碳水化合物替代治疗的儿童，在四至八周后肾功能和肝功能恢复正常出院。无需透析治疗。肝脏和肾脏异常肯定是由于第一天大量输注果糖、山梨醇和木糖醇，总量达7.1 - 23.0 g/kg，远高于推荐水平。
