Bergmann M, Silling-Engelhardt G, Schnabel R, Gulotta F
Institut für Neuropathologie, Universität Münster.
Z Gesamte Inn Med. 1991 Mar;46(4):101-6.
Report on three cases of a cerebro-renal oxalosis. The clinical picture was characterized by subacutely appearing coma and cerebral paroxysms. Death occurred due to break-down of cerebral regulation. In all three cases the post-mortem examination showed massive subendothelial depositions of double refractive crystals in the cerebral vessels, in particular in the stem ganglia regions and in the renal tubuli. The crystals showed several features typical for calcium oxalate. The clinical picture appears as an infrequent complication within intensive medicine, in connection with parenteral administration of xylit. Differential diagnosis, pathogenesis and possible cofactors are discussed.
三例脑肾草酸沉着症报告。临床表现为亚急性昏迷和脑部阵发性发作。因脑调节功能衰竭而死亡。所有三例尸检均显示脑血管尤其是脑干神经节区域和肾小管内有大量双折射晶体的内皮下沉积。这些晶体具有草酸钙的若干典型特征。该临床表现是重症医学中一种罕见的并发症，与木糖醇的胃肠外给药有关。文中讨论了鉴别诊断、发病机制及可能的辅助因素。
