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Strand symmetry of mutation rates in the beta-globin region.

作者信息

Bulmer M

机构信息

Department of Statistics, Oxford, UK.

出版信息

J Mol Evol. 1991 Oct;33(4):305-10. doi: 10.1007/BF02102861.

DOI:10.1007/BF02102861
PMID:1774785
Abstract

It has been suggested that there may be inequalities in the types of substitution on the two DNA strands (in particular, in the frequencies of transversions from R to Y and from Y to R) due to a higher error rate on the lagging than the leading strand during replication. Reexamination of 11 kb of the beta-globin region sequenced in six primates fails to confirm this suggestion. Examination of the 73-kb beta-globin region sequenced in humans shows that the frequency of pyrimidines in different parts of this region is more variable than expected in a random sequence, but the pattern is more consistent with nonrandomness generated by DNA turnover mechanisms than with strand asymmetry due to a higher error rate on the lagging strand.

摘要

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本文引用的文献

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DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication.DNA聚合酶准确性与自发突变率：DNA复制过程中嘌呤-嘌呤、嘌呤-嘧啶和嘧啶-嘧啶错配的频率
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哺乳动物基因组中与复制相关的链不对称性：迈向复制起点的检测
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