Kofman O, Belmaker R H, Grisaru N, Alpert C, Fuchs I, Katz V, Rigler O
Beer-Sheva Mental Health Center, Ben Gurion University of the Negev, Israel.
Psychopharmacol Bull. 1991;27(3):185-90.
Acute and chronic lithium treatment reduces levels of brain myo-inositol in rats. Several biological effects of lithium can be reversed in vitro by addition of myo-inositol. The ability of myo-inositol to reverse behavioral effects of lithium was tested using chronic inositol administration or acute intracerebroventricular (i.c.v.) injections. Chronic myoinositol elevated activity during the first 10 min in an open field, but did not reverse lithium-induced hypokinesia. Myo-inositol (i.c.v.) reversed the suppression of rearing behavior 24 hrs after an acute dose of lithium (5 mEq/kg) but did not attenuate hypokinesia 24 hrs after a high dose of lithium (10 mEq/kg). Myo-inositol, but not the inactive isomer chiro-inositol (i.c.v.), also significantly prolonged the latency to clonus in the lithium pilocarpine seizure model. These studies suggest that reduction of brain myo-inositol may be a critical mechanism for the behavioral effects of lithium.
急性和慢性锂治疗可降低大鼠脑内肌醇水平。锂的几种生物学效应在体外可通过添加肌醇而逆转。采用慢性给予肌醇或急性脑室内（i.c.v.）注射的方法，测试了肌醇逆转锂行为效应的能力。慢性肌醇在开放场中最初10分钟内可提高活动水平，但不能逆转锂诱导的运动减少。肌醇（i.c.v.）可逆转急性给予锂（5 mEq/kg）24小时后对竖毛行为的抑制，但不能减轻高剂量锂（10 mEq/kg）24小时后的运动减少。在锂-毛果芸香碱癫痫模型中，肌醇而非无活性的异构体手性肌醇（i.c.v.）也显著延长了阵挛潜伏期。这些研究表明，脑内肌醇的减少可能是锂行为效应的关键机制。
